GOAnno: GO annotation based on multiple alignment.

Frédéric Chalmel (1) , Aurélie Lardenois (1) , Julie D. Thompson (1) , Jean Muller (1) , José-Alain Sahel (2) , Thierry Léveillard (2) , Olivier Poch (1)

1 IGBMC - Institut de génétique et biologie moléculaire et cellulaire
2 Laboratoire de Physiopathologie Cellulaire et Moleculaire de la Retine

SUMMARY: GOAnno is a web tool that automatically annotates proteins according to the Gene Ontology (GO) using evolutionary information available in hierarchized multiple alignments. GO terms present in the aligned functional subfamily can be cross-validated and propagated to obtain highly reliable predicted GO annotation based on the GOAnno algorithm. AVAILABILITY: The web tool and a reduced version for local installation are freely available at http://igbmc.u-strasbg.fr/GOAnno/GOAnno.html SUPPLEMENTARY INFORMATION: The website supplies a detailed explanation and illustration of the algorithm at http://igbmc.u-strasbg.fr/GOAnno/GOAnnoHelp.html.

Domaines: Biologie moléculaire

Frédéric Chalmel, Aurélie Lardenois, Julie D. Thompson, Jean Muller, José-Alain Sahel, et al.. GOAnno: GO annotation based on multiple alignment.. Bioinformatics, 2005, 21 (9), pp.2095-6. ⟨10.1093/bioinformatics/bti252⟩. ⟨hal-00187483⟩