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In vivo MRI tracking of exogenous monocytes/macrophages targeting brain tumors in a rat model of glioma.

Abstract : This study has shown that murine monocytes/macrophages (Mo/Ma) can be labeled simply and efficiently with large, green-fluorescent, micrometer-sized particles of iron-oxide (MPIO). Neither size nor proliferation rate of the Mo/Ma is significantly affected by this labeling. The labeled Mo/Ma have been administered intravenously to rats that had developed a glioma following stereotactic injection of C6 cells. The labeled Mo/Ma were shown to target the brain tumors, a process that could be monitored non-invasively using T2*-weighted MRI. MRI observations were confirmed by Prussian blue staining, lectin staining and fluorescence histology. Overall, the results of this study suggest that the use of Mo/Ma may be envisaged in the clinic for vectorizing therapeutic agents towards gliomas.
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https://hal.archives-ouvertes.fr/hal-00178542
Contributor : Florence Couteau <>
Submitted on : Thursday, October 11, 2007 - 2:56:51 PM
Last modification on : Friday, November 6, 2020 - 3:48:54 AM

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Samuel Valable, Emmanuel Barbier, Myriam Bernaudin, Simon Roussel, Christoph Segebarth, et al.. In vivo MRI tracking of exogenous monocytes/macrophages targeting brain tumors in a rat model of glioma.. NeuroImage, Elsevier, 2007, 37 Suppl 1, pp.S47-58. ⟨10.1016/j.neuroimage.2007.05.041⟩. ⟨hal-00178542⟩

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