Genetics of the APM1 locus and its contribution to type 2 diabetes susceptibility in French Caucasians.

Fernando Gibson (1) , Philippe Froguel (1, 2, 3)

1 Section of Genomic Medicine
2 GMM - Génétique des maladies multifactorielles
3 Genome Centre

We have carried out a detailed reexamination of the genetics of the APM1 locus and its contribution to the genetic basis of type 2 diabetes susceptibility in the French Caucasian population. The G allele of single nucleotide polymorphism -11426 in the APM1 promoter showed modest association with type 2 diabetes (odds ratio 1.44 [95% CI 1.04-1.98]; P = 0.03), providing corroborative evidence that single nucleotide polymorphisms in the APM1 promoter region contribute to the genetic risk of type 2 diabetes. A "sliding window" analysis identified haplotypes 1-1-1, 1-1-1-1, and 1-1-1-1-1 as being strongly protective against type 2 diabetes (P

Domaines: Génétique humaine

Fernando Gibson, Philippe Froguel. Genetics of the APM1 locus and its contribution to type 2 diabetes susceptibility in French Caucasians.. Diabetes, 2004, 53 (11), pp.2977-83. ⟨hal-00174502⟩