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FCGR3B copy number variation is associated with susceptibility to systemic, but not organ-specific, autoimmunity.

Abstract : Naturally occurring variation in gene copy number is increasingly recognized as a heritable source of susceptibility to genetically complex diseases. Here we report strong association between FCGR3B copy number and risk of systemic lupus erythematosus (P = 2.7 x 10(-8)), microscopic polyangiitis (P = 2.9 x 10(-4)) and Wegener's granulomatosis in two independent cohorts from the UK (P = 3 x 10(-3)) and France (P = 1.1 x 10(-4)). We did not observe this association in the organ-specific Graves' disease or Addison's disease. Our findings suggest that low FCGR3B copy number, and in particular complete FCGR3B deficiency, has a key role in the development of systemic autoimmunity.
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https://hal.archives-ouvertes.fr/hal-00173649
Contributor : Philippe Froguel <>
Submitted on : Thursday, September 20, 2007 - 12:22:42 PM
Last modification on : Thursday, February 21, 2019 - 9:56:02 AM

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Manuela Fanciulli, Penny J Norsworthy, Enrico Petretto, Rong Dong, Lorraine Harper, et al.. FCGR3B copy number variation is associated with susceptibility to systemic, but not organ-specific, autoimmunity.. Nature Genetics, Nature Publishing Group, 2007, 39 (6), pp.721-3. ⟨10.1038/ng2046⟩. ⟨hal-00173649⟩

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