Expression of CD94-NKG2A inhibitory receptor is restricted to a subset of CD8+ T cells.

Veronique M Braud (1) , Hatice Aldemir (1) , Beatrice Breart (1) , Walter G Ferlin (1)

1 IPMC - Institut de pharmacologie moléculaire et cellulaire

Natural killer (NK)-cell receptors (NKRs) on CD8+ T cells can modulate antigen-specific T-cell activity but their function and rules that govern their expression remain unclear. Recent work has provided new insight into CD94-NKG2A expression on T cells. Whereas upregulation on the cell surface is induced following T-cell receptor (TCR) engagement, commitment to CD94-NKG2A expression is a clonal attribute. NKRs can therefore shape cytotoxic T-lymphocyte (CTL) responses and should be considered in designing vaccine therapies.

Domains: Immunology

Veronique M Braud, Hatice Aldemir, Beatrice Breart, Walter G Ferlin. Expression of CD94-NKG2A inhibitory receptor is restricted to a subset of CD8+ T cells.. Trends in Immunology, 2003, 24 (4), pp.162-4. ⟨hal-00170963⟩