Fluorinated and hemifluorinated surfactants derived from maltose: Synthesis and application to handling membrane proteins in aqueous solution

Ange Polidori (1) , Marc Presset (1) , Florence Lebaupain (2) , Bruno Ameduri (3, 4) , Jean-Luc Popot (2) , Cécile Breyton , Bernard Pucci (1)

1 LCBOSMV - Laboratoire de Chimie Bioorganique et des Systèmes Moléculaires Vectoriels
2 PCMMB - Physico-chimie moléculaire des membranes biologiques
3 ICGM ICMMM - Institut Charles Gerhardt Montpellier - Institut de Chimie Moléculaire et des Matériaux de Montpellier
4 LSIC - ENSCM - Laboratoire des Systèmes d'Information Chimique

Two novel fluorinated surfactants have been obtained by grafting by radical reaction either a fluorocarbon or an ethyl end-capped fluorocarbon chain onto the double bond of b-D-allyl maltose. The two compounds thus obtained form polydisperse aggregates in water. They can keep membrane proteins water-soluble, but the protein/surfactant complexes are polydisperse, which affects neither the native state nor the stability of the proteins.

Mots clés: Aggregates

Mots clés: Fluorinated surfactants; Maltoside; Membrane proteins; Solubilization; Aggregates.

Domaines: Polymères

Ange Polidori, Marc Presset, Florence Lebaupain, Bruno Ameduri, Jean-Luc Popot, et al.. Fluorinated and hemifluorinated surfactants derived from maltose: Synthesis and application to handling membrane proteins in aqueous solution. Bioorganic and Medicinal Chemistry Letters, 2006, 16, pp.5827-5831. ⟨10.1016/j.bmcl.2006.08.070⟩. ⟨hal-00182243⟩