Maintenance of HIV-specific central and effector memory CD4 and CD8 T cells requires antigen persistence.

Urban Sester , Martina Sester (1) , Hans Köhler , Hans W Pees , Barbara C Gärtner , Simon Wain-Hobson (2) , Gennady Bocharov , Andreas Meyerhans

1 BGA - Biologie et Gestion des Adventices
2 Rétrovirologie Moléculaire

The HIV-specific central and effector CD4 and CD8 memory T cell populations disappear from the peripheral blood of infected individuals under highly active antiretroviral therapy (HAART) with a mean half-life of 6.0 and 7.7 months, respectively. By contrast, cytomegalovirus (CMV)-specific responses are stable or increase. The striking quantitative differences between T cell memory to two persistent viral infections are instructive as to how antigen dosage contributes to the maintenance of antigen-specific memory T cell responses in humans.

Mots clés: Kinetics; T-Lymphocyte Subsets; T-Lymphocytes; Cytotoxic; Viral Load; Antiretroviral Therapy; Highly Active; CD4-Positive T-Lymphocytes; CD8-Positive T-Lymphocytes; Cytomegalovirus; HIV Infections; HIV-1; Humans; Immunologic Memory

Domaines: Virologie

Urban Sester, Martina Sester, Hans Köhler, Hans W Pees, Barbara C Gärtner, et al.. Maintenance of HIV-specific central and effector memory CD4 and CD8 T cells requires antigen persistence.. AIDS Research and Human Retroviruses, 2007, 23 (4), pp.549-53. ⟨10.1089/aid.2006.0234⟩. ⟨hal-00167684⟩