Ethyl Propiolate: A Simple and Convenient Peptide Coupling Reagent

Jean-Marc Campagne (1) , Bogdan Iorga (1)

1 ICSN - Institut de Chimie des Substances Naturelles

Ethyl propiolate has been used to activate N-protected amino acids to form a moderately activated vinyl-ester which aminolysis requires a catalytic amount of sodium bisulfite.

Mots clés: peptide; coupling reagent; sodium bisulfite

Domaines: Chimie organique

Jean-Marc Campagne, Bogdan Iorga. Ethyl Propiolate: A Simple and Convenient Peptide Coupling Reagent. SYNLETT, 2004, pp.1826. ⟨10.1055/s-2004-829553⟩. ⟨hal-00165649⟩