Deletions of the endocytic components VPS28 and VPS32 in Candida albicans lead to echinocandin and azole hypersensitivity.

Muriel Cornet (1, 2) , Claude Gaillardin (2) , Mathias L Richard (2)

1 Microbiologie, Hôtel-Dieu,
2 MGM - Microbiologie et Génétique Moléculaire

Vps28p and Vps32p act in both the endocytic and the pH signaling pathways in yeasts and are required for Candida albicans virulence. Here, we show that deletions of VPS28 and VPS32 increase the susceptibility of C. albicans to cell wall disruption agents, echinocandin and azole antifungal agents.

Mots clés: PH AMBIANT SIGNALLING; ANTIFUNGAL AGENT; VPS28; VPS32; CANDIDA ALBICANS; VIRULENCE; GENE EXPRESSION REGULATION

Mots clés: VESICULAR TRANSPORT PROTEIN

Domaines: Biologie moléculaire

Muriel Cornet, Claude Gaillardin, Mathias L Richard. Deletions of the endocytic components VPS28 and VPS32 in Candida albicans lead to echinocandin and azole hypersensitivity.. Antimicrobial Agents and Chemotherapy, 2006, 50 (10), pp.3492-5. ⟨10.1128/IAI.73.12.7977-7987.2005⟩. ⟨hal-00164053⟩