New homogeneously and heterogeneously [Pd/Cu]-catalysed C3-alkenylation of free NH-indoles

L. Djakovitch (1) , P. Rouge

1 IRCELYON - Institut de recherches sur la catalyse et l'environnement de Lyon

A new palladium/copper catalytic procedure for the C3-alkenylation of free NH-indoles is reported. Using homogeneous or heterogeneous hetero-bimetallic [Pd/Cu]-catalysts under mild reaction conditions (10 mol% Pd-catalyst and 10 mol% Cu-catalyst, 70°C, air), substituted indoles are fully (58-82% isolated yields) and selectively (75-100% selectivity) converted to the expected 2-substituted-3-vinyl indoles.

Domaines: Chimie inorganique; Environnement et Société

L. Djakovitch, P. Rouge. New homogeneously and heterogeneously [Pd/Cu]-catalysed C3-alkenylation of free NH-indoles. Journal of Molecular Catalysis A: Chemical, 2007, 273, pp.230-239. ⟨10.1016/j.molcata.2007.04.011⟩. ⟨hal-00151664⟩