The role of the extra cellular matrix on memory

Nathalie Olivi-Tran (1) , Sandra Kanani (2) , Ian Robbins (2)

1 LPMCN - Laboratoire de Physique de la Matière Condensée et Nanostructures
2 IGMM - Institut de Génétique Moléculaire de Montpellier

We expose a model of memory based on one hand of the mechanical oscillations of axons during action potential and on the other hand on the changes in the extra cellular matrix composition when a mechanical strain is applied on it. Due to these changes, the stiffness of the extra cellular matrix along the most excited neurons will increase close to these neurons. This will create preferential paths linked to a memory effect. The role of paradoxical sleep is to enhance the mechanical action on the extra cellular matrix.

Mots clés: extra cellular matrix; neurons; memory

Domaines: Neurobiologie

Nathalie Olivi-Tran, Sandra Kanani, Ian Robbins. The role of the extra cellular matrix on memory. 2007. ⟨hal-00134775v1⟩