Carbonic anhydrase inhibitors : Clash with Ala65 as a Means for designing inhibitors with low affinity for the ubiquitous isozyme II, exemplified by the crystal structure of the topiramate sulfamide analogue

Jean-Yves Winum (1) , Claudia Temperini (2) , Khaled El Cheikh (1) , Alessio Innocenti (2) , Daniela Vullo (2) , Samuele Ciattini (3) , Jean-Louis Montero (1) , Andrea Scozzafava (2) , Claudiu T. Supuran (2)

1 LCB - Laboratoire de chimie biomoléculaire
2 LCBI-UniFI - Laboratorio di Chimica Bioinorganica [UniFI, Firenze] = Laboratory of Bioinorganic Chemistry [UniFI Florence]
3 Centro Interdipartimentale di Cristallografia

Domaines: Chimie organique

Jean-Yves Winum, Claudia Temperini, Khaled El Cheikh, Alessio Innocenti, Daniela Vullo, et al.. Carbonic anhydrase inhibitors : Clash with Ala65 as a Means for designing inhibitors with low affinity for the ubiquitous isozyme II, exemplified by the crystal structure of the topiramate sulfamide analogue. Journal of Medicinal Chemistry, 2006, 49, pp.7024-7031. ⟨hal-00127733⟩