Convergent Routes to Substituted Naphthylamides

Ngoc Diem My Tran (1) , Samir Z. Zard (1)

1 DCSO - Laboratoire de synthèse organique

Practical, convergent routes to variously substituted 1- and 2-naphthylamides have been developed. They exploit the ability of xanthates to undergo both intermolecular radical additions to vinyl pivalate and intramolecular radical cyclisations to aromatic rings. In the case of 1-naphthylamides, the existence of an intramolecular hydrogen bond was used to facilitate the cyclisation step.

Domaines: Chimie organique

Ngoc Diem My Tran, Samir Z. Zard. Convergent Routes to Substituted Naphthylamides. Organic & Biomolecular Chemistry, 2014, 12 (20), pp.3251-3264. ⟨10.1039/C4OB00339J⟩. ⟨hal-00109943⟩