The Jak-STAT signaling pathway is required but not sufficient for the antiviral response of drosophila.

Catherine Dostert (1) , Emmanuelle Jouanguy (1) , Philabeg Irving (1) , Laurent Troxler (1) , Galiana Delphine (1) , Charles Hetru (1) , Jules A. Hoffmann (1) , Jean-Luc Imler (1)

1 RIDI - UPR 9002 - Réponse immunitaire et developpement chez les insectes

The response of drosophila to bacterial and fungal infections involves two signaling pathways, Toll and Imd, which both activate members of the transcription factor NF-kappaB family. Here we have studied the global transcriptional response of flies to infection with drosophila C virus. Viral infection induced a set of genes distinct from those regulated by the Toll or Imd pathways and triggered a signal transducer and activator of transcription (STAT) DNA-binding activity. Genetic experiments showed that the Jak kinase Hopscotch was involved in the control of the viral load in infected flies and was required but not sufficient for the induction of some virus-regulated genes. Our results indicate that in addition to Toll and Imd, a third, evolutionary conserved innate immunity pathway functions in drosophila and counters viral infection.

Domaines: Biologie moléculaire; Biologie cellulaire

Catherine Dostert, Emmanuelle Jouanguy, Philabeg Irving, Laurent Troxler, Galiana Delphine, et al.. The Jak-STAT signaling pathway is required but not sufficient for the antiviral response of drosophila.. Nature Immunology, 2005, 6, pp.946-953. ⟨hal-00094350⟩