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Mycobacterial lipomannan induces matrix metalloproteinase-9 expression in human macrophagic cells through a Toll-like receptor 1 (TLR1)/TLR2- and CD14-dependent mechanism.

Abstract : Lipomannans (LM) from various mycobacterial species were found to induce expression and secretion of the matrix metalloproteinase 9 (MMP-9) both in human macrophage-like differentiated THP-1 cells and in primary human macrophages. Inhibition studies using antireceptor-neutralizing antibodies are indicative of a Toll-like receptor 1 (TLR1)/TLR2- and CD14-dependent signaling mechanism. Moreover, LM was shown to down-regulate transcription of the metalloproteinase inhibitor TIMP-1, a major endogenous MMP-9 regulator.
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https://hal.archives-ouvertes.fr/hal-00087033
Contributor : Yann Guérardel <>
Submitted on : Friday, July 21, 2006 - 9:13:37 AM
Last modification on : Tuesday, May 12, 2020 - 6:36:06 PM

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  • HAL Id : hal-00087033, version 1

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Elisabeth Elass, Laetitia Aubry, Maryse Masson, Denys Agnès, Yann Guérardel, et al.. Mycobacterial lipomannan induces matrix metalloproteinase-9 expression in human macrophagic cells through a Toll-like receptor 1 (TLR1)/TLR2- and CD14-dependent mechanism.. Infection and Immunity, American Society for Microbiology, 2005, 73, pp.7064-7068. ⟨hal-00087033⟩

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