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The slit receptor Rig-1/Robo3 controls midline crossing by hindbrain precerebellar neurons and axons.

Abstract : During development, precerebellar neurons migrate dorsoventrally from the rhombic lip to the floor plate. Some of these neurons cross the midline while others stop. We have identified a role for the slit receptor Rig-1/Robo3 in directing this process. During their tangential migration, neurons of all major hindbrain precerebellar nuclei express high levels of Rig-1 mRNA. Rig-1 expression is rapidly downregulated as their leading process crosses the floor plate. Interestingly, most precerebellar nuclei do not develop normally in Rig-1-deficient mice, as they fail to cross the midline. In addition, inferior olivary neurons, which normally send axons into the contralateral cerebellum, project ipsilaterally in Rig-1 mutant mice. Similarly, neurons of the lateral reticular nucleus and basilar pons are unable to migrate across the floor plate and instead remain ipsilateral. These results demonstrate that Rig-1 controls the ability of both precerebellar neuron cell bodies and their axons to cross the midline.
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https://hal.archives-ouvertes.fr/hal-00080701
Contributor : Therese Ghembaza <>
Submitted on : Tuesday, June 20, 2006 - 11:24:24 AM
Last modification on : Friday, March 13, 2020 - 1:56:45 PM

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V. Marillat, C. Sabatier, V. Failli, E. Matsunaga, C. Sotelo, et al.. The slit receptor Rig-1/Robo3 controls midline crossing by hindbrain precerebellar neurons and axons.. Neuron, Elsevier, 2004, 43, pp.69-79. ⟨10.1016/j.neuron.2004.06.018⟩. ⟨hal-00080701⟩

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