Hybrid materials applied to biotechnologies: coating of calcium phosphates for the design of implants active against bone resorption disorders

H. Roussière (1) , Gilles F Montavon (2) , S. Laïb (1) , P. Janvier (1) , B. Alonso (3) , F. Fayon (3) , M. Petit (1) , D. Massiot (3) , J.M. Bouler , B. Bujoli (1)

1 LSOHOOM - Laboratoire de Synthèse Organique (Hétérochimie organique, organoéléments et matériaux)
2 SUBATECH - Laboratoire SUBATECH Nantes
3 CRMHT - Centre de recherches sur les matériaux à haute température

The reaction of a bisphosphonate bone resorption inhibitor (Zoledronate) with calcium deficient hydroxyapatites (CDAs) was studied as a potential route to local drug delivery systems active against bone resorption disorders. A simple mathematical model of the Zoledronate–CDA interaction was designed that correctly described the adsorption of Zoledronate onto CDAs. The resulting Zoledronate-loaded materials were found to release the drug in different phosphate-containing media, with a satisfactory agreement between experimental data and the values predicted from the model.

Mots clés: NMR; Hybrid Materials

Domaines: Chimie-Physique [physics.chem-ph]; Physique Médicale [physics.med-ph]

H. Roussière, Gilles F Montavon, S. Laïb, P. Janvier, B. Alonso, et al.. Hybrid materials applied to biotechnologies: coating of calcium phosphates for the design of implants active against bone resorption disorders. Journal of Materials Chemistry, 2005, 15, pp.3869-3875. ⟨10.1039/b503680a⟩. ⟨hal-00017044⟩