A rapid access to spiroaminoketal framework.

Ahmatjan Tursun (1) , Anne-Sophie Martin (1) , Bettina Aboab (1) , Marie-Eve Sinibaldi (1) , Isabelle Canet (1)

1 SEESIB - Synthèse et étude de systèmes à intêret biologique

A convergent and stereoselective synthesis of 1-oxa-7-azaspiro[5.5]undecane is described. This functional new spiroheterocycle is readily available from acetone ?n?-dimethylhydrazone via a double alkylation and subsequent spiroannulation process.

Mots clés: Spiro compounds; alkylations; hydrazones; synthesis; amino acid

Domaines: Chimie organique

Ahmatjan Tursun, Anne-Sophie Martin, Bettina Aboab, Marie-Eve Sinibaldi, Isabelle Canet. A rapid access to spiroaminoketal framework.. SYNLETT, 2005, 15, pp.2397-2399. ⟨10.1055/s-2005-872665⟩. ⟨hal-00012179⟩