Interaction of Alamethicin Pores in DMPC Bilayers

Abstract : We have investigated the X-ray scattering signal of highly aligned multilayers of the zwitterionic lipid 1,2-dimyristoyl-sn-glycero-3-phosphatidylcholine containing pores formed by the antimicrobial peptide alamethicin as a function of the peptide/lipid ratio. We are able to obtain information on the structure factor of the pore fluid which then yields the interaction potential between pores in the plane of the bilayers. Aside from a hard core with a radius corresponding to the geometric radius of the pore, we find a repulsive lipid-mediated interaction with a range of about 30 Å and a contact value of 2.4 kBT. This result is in qualitative agreement with recent theoretical models.
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Biophysical Journal, Biophysical Society, 2007, 92 (11), pp.3978-3987
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Doru Constantin, Guillaume Brotons, Ansgar Jarre, Chenghao Li, Tim Salditt. Interaction of Alamethicin Pores in DMPC Bilayers. Biophysical Journal, Biophysical Society, 2007, 92 (11), pp.3978-3987. <hal-00128428>

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