Numerical modeling of cartilage growth under mechanical stresses. Mechanical and biological analysis on in vitro «micropellet» model

Marie Maumus (1) , Gilles Dusfour (2, 3) , S. Lefloch (2, 3) , Dominique Ambard (2, 3) , Christian Jorgensen (1) , Danièle Noël (1) , Patrick Cañadas (2, 3)

1 Cellules Souches, Plasticité Cellulaire, Médecine Régénératrice et Immunothérapies (IRMB)
2 LMGC - Laboratoire de Mécanique et Génie Civil
3 BIOTIC - Biomécanique des Interactions et de l'Organisation des Tissus et des Cellules

The project concerns the modeling of the growth of new-cartilage samples generated from mesenchymal stem cells. These samples reproduce the embryonic formation of cartilage. We first propose to set up a device for analysing the mechanical features of neocartilage samples and then to investigate the role of mechanical stresses on the extra-cellular matrix production. This approach aims at evaluating and classifying the influence of mechanical stresses in respect of the growth factors on growth process.

Mots clés: Cartilage; growth; mechanical stresses; micropellet; mechanotransduction

Domaines: Biomécanique [physics.med-ph]

Marie Maumus, Gilles Dusfour, S. Lefloch, Dominique Ambard, Christian Jorgensen, et al.. Numerical modeling of cartilage growth under mechanical stresses. Mechanical and biological analysis on in vitro «micropellet» model. 5èmes journées scientifique du Labex Numev, Oct 2016, Montpellier, France. 2016. ⟨hal-01772220⟩