Eight flavonoids and their potential as inhibitors of human cytomegalovirus replication

Abstract : The drugs currently available for treatment of severe human cytomegalovirus (HCMV) infections suffer from many drawbacks, particularly toxicity, and potential teratogenicity contraindicating their use in tar- get populations such as pregnant women. The emergence of drug-resistant strains is still a problem for disease management, particularly in immunosuppressed populations where antivirals are used for extended periods of time. The flavonoid family of drugs contains promising candidates as they have low toxicity and inhibit different targets to currently available antivirals. We report here that, unlike their chalcon homologs, four flavonoids (baicalein, quercetin, quercetagetin and naringenin) inhibit various stages of HCMV replication, the most active anti-HCMV compound being baicalein and the less active and less selective being quercetagetin. These drugs could provide potential inhibitors of virus replication alone or in combination, without increased toxicity
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Soumis le : mardi 27 octobre 2015 - 16:53:24
Dernière modification le : mardi 26 février 2019 - 10:12:38




Sébastien Cotin, Claude-Alain Calliste, Marie-Christine Mazeron, Sébastien Hantz, Jean-Luc Duroux, et al.. Eight flavonoids and their potential as inhibitors of human cytomegalovirus replication. Antiviral Research, Elsevier Masson, 2012, 96 (2), pp.181-186. ⟨10.1016/j.clay.2015.03.020⟩. ⟨hal-01221310⟩



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