New thymine-based derivative of nitrogen mustards.

Benjamin Boëns (1) , Karine Teste (1) , Amel Hadj-Bouazza (2) , Jihane Ismaili (3) , Rachida Zerrouki (1)

1 LCSN - Laboratoire de Chimie des Substances Naturelles
2 Centre de Recherche sur les Matériaux Lignocellulosiques
3 Laboratoire de Chimie Organique

This work deals with the synthesis of a new nitrogen mustard derivative based on thymine. To introduce the bis(2-chloroethyl)amine group to position 4 of the pyrimidine base, many strategies were explored and the desired compound was finally obtained, thanks to a synthetic pathway in five steps.

Domaines: Chimie organique

Benjamin Boëns, Karine Teste, Amel Hadj-Bouazza, Jihane Ismaili, Rachida Zerrouki. New thymine-based derivative of nitrogen mustards.. Nucleosides, Nucleotides and Nucleic Acids, 2012, 31 (3), pp.197-205. ⟨10.1080/15257770.2011.649330⟩. ⟨hal-00697254⟩