Mitochondria and the reactive species interactome: shaping the future of mitoredox medicine

Laurent Chatre (1)

1 ISTCT - Imagerie et Stratégies Thérapeutiques pour les Cancers et Tissus cérébraux

Redox medicine improvement could come from integrating insights from both the mitochondria and redox fields. One-step further is finding new clues with a comprehensive discussion of the two fields, and their relationship, including through the reactive species interactome (RSI). Here, the review provides a platform for future studies focusing on both mitochondria and the RSI. Mitochondria are discussed at length with focus on the mitochondrial permeability transition pore, the regulation of cell death types, the protein quality control system, calcium homoeostasis, ionome, metabolome, mitochondrial carriers, and organelle interaction. Then, the RSI is discussed focusing on its relationship with mitochondria. Finally, the mitochondria-RSI axis is proposed as a brand-new perspective, including with the involvement of the circadian clock and bacterial microbiota, as the first stone of the concept of MitoRedox Medicine.

Mots clés: Mitochondria; reactive species interactome; redox medicine

Domaines: Sciences du Vivant [q-bio]

Laurent Chatre. Mitochondria and the reactive species interactome: shaping the future of mitoredox medicine. Journal of Mitochondria, Plastids and Endosymbiosis, 2024, 2 (1), pp.1-38. ⟨10.1080/28347056.2024.2304348⟩. ⟨hal-04452758⟩