Models of biological effects of radiation in the Geant4 Toolkit

S. Chauvie , Z. Francis (1) , S. Guatelli , S. Incerti (2) , B. Mascialino , Gerard Montarou (1) , P. Moretto (2) , P. Nieminen , M.G. Pia

1 LPC - Laboratoire de Physique Corpusculaire - Clermont-Ferrand
2 CENBG - Centre d'Etudes Nucléaires de Bordeaux Gradignan

A project, named Geant4-DNA, is in progress to extend the Geant4 simulation toolkit to model the effects of radiation with biological systems at cellular and DNA level. The first component implemented in the first development cycle of the project describes the fractional survival of a population of cells irradiated with photons or charged particles. The software system developed provides the user the option to choose among a small set of alternative models for the calculation of mammalian cell survival after irradiation. The flexible design adopted makes the system open to further extension to implement other cell survival models available in literature. The preliminary design of a prototype of the cell survival models implemented and preliminary results in some selected cell lines are described.

Mots clés: MonteCarlo; Geant4; Radiobiological damage; Radiobiological modeling; Cell survival

Domaines: Biophysique [physics.bio-ph]; Instrumentations et Détecteurs [physics.ins-det]

S. Chauvie, Z. Francis, S. Guatelli, S. Incerti, B. Mascialino, et al.. Models of biological effects of radiation in the Geant4 Toolkit. 2006 IEEE Nuclear Science Symposium (NSS), Medical Imaging Conference (MIC) And 15th International Room Temperature Semiconductor Detector Workshop, Oct 2006, San Diego, United States. ⟨in2p3-00134456⟩