On-chip in-situ observations of crystallization events under supercritical CO2

Fatma Ercicek (1, 2) , Olivier Nguyen (1) , Arnaud Erriguible (1) , Christelle Harscoat-Schiavo (2) , Pascale Subra-Paternault (2) , Samuel Marre (1)

1 ICMCB - Institut de Chimie de la Matière Condensée de Bordeaux
2 CBMN - Chimie et Biologie des Membranes et des Nanoobjets

Crystallization represents a key unit operation in separation and purification processes in the pharmaceutical industry, about 90% of active pharmaceutical ingredients (API) being obtained by this technique1. Most APIs are chiral and poorly soluble in water and therefore have a low bioavailability. Understanding crystallization process can help to obtain products with desired properties. The challenge for industries is to be able to produce directly highly water soluble and/or enantiopure drugs without going through several purification steps, which are costly, solvent and time consuming...

Domaines: Matériaux; Génie chimique

Fatma Ercicek, Olivier Nguyen, Arnaud Erriguible, Christelle Harscoat-Schiavo, Pascale Subra-Paternault, et al.. On-chip in-situ observations of crystallization events under supercritical CO2. 13th International Symposium on Supercritical Fluids (ISSF 2022), International Society for the Advancement of Supercritical Fluids, May 2022, Montréal, Canada. 2 p. ⟨hal-04187709⟩