Polymersome Popping by Light-Induced Osmotic Shock under Temporal, Spatial, and Spectral Control

Ariane Peyret (1, 2) , Emmanuel Ibarboure (1, 2) , Arnaud Tron (3) , Louis Beauté (1, 2) , Ruben Rust (3) , Olivier Sandre (2, 1) , Nathan Mcclenaghan (3) , Sébastien Lecommandoux (1, 2)

1 LCPO - Laboratoire de Chimie des Polymères Organiques
2 Team 3 LCPO : Polymer Self-Assembly & Life Sciences
3 ISM - Institut des Sciences Moléculaires

The light-triggered, programmable rupture of cellsized vesicles is described, with particular emphasis on selfassembled polymersome capsules. The mechanism involves a hypotonic osmotic imbalance created by the accumulation of photogenerated species inside the lumen, which cannot be compensated owing to the low water permeability of the membrane. This simple and versatile mechanism can be adapted to a wealth of hydrosoluble molecules, which are either able to generate reactive oxygen species or undergo photocleavage. Ultimately, in a multi-compartmentalized and cell-like system, the possibility to selectively burst polymersomes with high specificity and temporal precision and to consequently deliver small encapsulated vesicles (both polymersomes and liposomes) is demonstrated.

Mots clés: Membrane proes; Polymerosomes; Liposomes; Osmotic pressure; Photochemistry; Coumarin; Uncaging

Domaines: Matériaux; Polymères

Ariane Peyret, Emmanuel Ibarboure, Arnaud Tron, Louis Beauté, Ruben Rust, et al.. Polymersome Popping by Light-Induced Osmotic Shock under Temporal, Spatial, and Spectral Control. Angewandte Chemie International Edition, 2017, 56 (6), pp.1566-1570. ⟨10.1002/ange.201609231⟩. ⟨hal-01418924⟩