Protein-Protein Interactions Focused Libraries for Drug Discovery

Dmytrenko Andrey (1)

1 CENBG - Centre d'Etudes Nucléaires de Bordeaux Gradignan

iPPI TreeTM library was designed using decision tree algorithm based on several molecular shape and functional group descriptors. iPPI AnalogsTM library was prepared by similarity search (ECFP4 fingerprints, minimum Tanimoto index is 0.4) with known active PPI inhibitors from TIMBAL database.

Mots clés: Protein-protein interactions; cancer; inflammation; autoimmune diseases; diabetes; osteoporosis; infection; inhibitors; compound libraries

Domaines: Biotechnologie; Biotechnologies

Dmytrenko Andrey. Protein-Protein Interactions Focused Libraries for Drug Discovery. 2013. ⟨hal-00862169⟩