Sterilization of liquid and semi-solid pharmaceutical forms using high pressure technology

Yohan Rigaldie (1, 2, 3) , Alain Largeteau (1) , Gilles Lemagnen (3) , Denis Larrouture (3) , R. Haller (2) , Gérard Demazeau (1) , Luc Grislain (3)

1 ICMCB - Institut de Chimie de la Matière Condensée de Bordeaux
2 Ellipse Pharmaceutical
3 LTIP - Laboratoire de Technologie Pharmaceutique Industrielle

The aim of this study was to investigate the use of HHP (High Hydrostatic Pressure) technology as a possible alternative method for decontamination and sterilization of sensitive drugs. We demonstrated the safety of HHP treatment on several sensitive biomolecules. A 10 min. HHP treatment inactivates totally pure suspensions of P. aeruginosa , C. albicans and spores of A. niger , but S. aureus needs a longer HHP duration treatment to be totally inactivated. Endospores appear to be more baroresistant.

Mots clés: High Pressure; Pharmacy; Sterilization; Fragile Drugs; Pharmacopoeia Strains

Domaines: Matériaux

Yohan Rigaldie, Alain Largeteau, Gilles Lemagnen, Denis Larrouture, R. Haller, et al.. Sterilization of liquid and semi-solid pharmaceutical forms using high pressure technology. High Pressure Research, 2002, 22 (3-4), pp.747-749. ⟨10.1080/08957950212456⟩. ⟨hal-00715319⟩