A zinc-sensing glucose-based naphthyl imino conjugate as a detecting agent for inorganic and organic phosphates, including DNA

Atanu Mitra (1) , Vijaya Kumar Hinge (1) , Ankit Mittal (1) , Snehasis Bhakta (1) , Philippe Guionneau (2) , Chebrolu P. Rao (1)

1 Bioinorganic Laboratory, Department of Chemistry
2 ICMCB - Institut de Chimie de la Matière Condensée de Bordeaux

Sugars' sense of zinc: A glucose-based naphthylimino conjugate (L) has been synthesized and structurally characterized. L has been shown to exhibit selective turn-on fluorescence towards Zn²⁺ in an aqueous alcoholic medium. The zinc complex, in turn, recognizes phosphates, nucleotides, and DNA by turn-off fluorescence, which has been further investigated by molecular dynamics simulations.

Mots clés: Fluorescence; Glycoconjugates; Molecular dynamics; Sensors; Zinc

Domaines: Matériaux

Atanu Mitra, Vijaya Kumar Hinge, Ankit Mittal, Snehasis Bhakta, Philippe Guionneau, et al.. A zinc-sensing glucose-based naphthyl imino conjugate as a detecting agent for inorganic and organic phosphates, including DNA. Chemistry - A European Journal, 2011, 17 (29), pp.8044-8047. ⟨10.1002/chem.201100734⟩. ⟨hal-00608547⟩