Grafting RGD containing peptides onto hydroxyapatite to promote osteoblastic cells adhesion

Marie-Christine Durrieu (1) , S. Pallu (1) , Fabien Guillemot (1) , Reine Bareille (1) , Joëlle Amédée (1) , Charles Baquey (1, 2) , Christine Labrugère (3) , M. Dard (4)

1 Biomateriaux et Reparation Tissulaire
2 Laboratoire de Biophysique
3 ICMCB - Institut de Chimie de la Matière Condensée de Bordeaux
4 Biomet-Merck Biomaterials

Ceramics possess osteoconductive properties but exhibit no intrinsic osteoinductive capacity. Consequently, they are unable to induce new bone formation in extra osseous sites. In order to develop bone substitutes with osteogenic properties, one promising approach consists of creating hybrid materials by associating in vitro biomaterials with osteoprogenitor cells...

Mots clés: Hydroxyapatite; Bone; Adhesion; Molecular or cellular Osteoblast; RGD peptides; Biomaterials; Prosthetic materials and Prosthetics

Domaines: Matériaux; Biotechnologies; Biotechnologie

Marie-Christine Durrieu, S. Pallu, Fabien Guillemot, Reine Bareille, Joëlle Amédée, et al.. Grafting RGD containing peptides onto hydroxyapatite to promote osteoblastic cells adhesion. Journal of Materials Science: Materials in Medicine, 2004, 19 (7), pp.779-786. ⟨10.1023/B:JMSM.0000032818.09569.d9⟩. ⟨hal-00158401⟩