Procédé de fabrication d'une forme pharmaceutique à libération contrôlée contenant au moins un principe actif
Résumé
A manufg. process for an administrable or implantable controlled-release dosage form contg. at least an active ingredient comprises mixing the active ingredients with a vector comprising one or more excipients and subjecting the mixt. to a treatment by high isostatic pressure ranging from 100-700 MPa for a length of time ranging between 1 and 60 min, to form the pharmaceutical form. Pharmaceutical forms obtained by this process are implanted or administered by oral, nasal, parenteral, vaginal, rectal or ophthalmic route. A tablet contg. ibuprofen 60, lactose 35, talc 4, colloidal silica 0.5, and magnesium stearate 0.5% was prepd. according to the above process.