Benchmarking of survival outcomes following haematopoietic stem cell transplantation: a review of existing processes and the introduction of an international system from the european society for blood and marrow transplantation (ebmt) and the joint accreditation committee of isct and ebmt (jacie)

John A. Snowden , Riccardo Saccardi , Kim Orchard , Per Ljungman , Rafael F. Duarte , Myriam Labopin , Eoin Mcgrath , Nigel Brook , Carmen Ruiz de Elvira , Debra Gordon , Helene A. Poirel , Francis Ayuk , Yves Beguin , Francesca Bonifazi , Alois Gratwohl , Noel Milpied , John Moore , Jakob Passweg , J. Douglas Rizzo , Stephen R. Spellman , Jorge Sierra , Carlos Solano , Fermin Sanchez-Guijo , Nina Worel , Andreu Gusi , Gillian Adams , Theodor Balan , Helen Baldomero , Gilles Macq , Evelyne Marry (1) , Florence Mesnil (1) , Elena Oldani , Rachel Pearce , Julia Perry , Nicole Raus , Urs Schanz , Steven Tran , Leonie Wilcox , Gzregorz Basak , Christian Chabannon (2) , Selim Corbacioglu , Harry Dolstra , Jurgen Kuball , Mohamad Mohty (3) , Arjan Lankester , Silvia Montoto , Arnon Nagler , Jan Styczynski , Ibrahim Yakoub-Agha (4) , Regis Peffault de Latour (5) , Nicolaus Kroger , Ronald Brand , Liesbeth C. de Wreede , Erik van Zwet , Hein Putter

1 Agence de la biomédecine [Saint-Denis la Plaine]
2 CIC - Biotherapie - Marseille
3 UPMC - Université Pierre et Marie Curie - Paris 6
4 LIRIC - Lille Inflammation Research International Center - U 995
5 UPD7 - Université Paris Diderot - Paris 7

In many healthcare settings, benchmarking for complex procedures has become a mandatory requirement by competent authorities, regulators, payers and patients to assure clinical performance, cost-effectiveness and safe care of patients. In several countries inside and outside Europe, benchmarking systems have been established for haematopoietic stem cell transplantation (HSCT), but access is not universal. As benchmarking is now integrated into the FACT-JACIE standards, the EBMT and JACIE established a Clinical Outcomes Group (COG) to develop and introduce a universal system accessible across EBMT members. Established systems from seven European countries (United Kingdom, Italy, Belgium, France, Germany, Spain, Switzerland), USA and Australia were appraised, revealing similarities in process, but wide variations in selection criteria and statistical methods. In tandem, the COG developed the first phase of a bespoke risk-adapted international benchmarking model for one-year survival following allogeneic and autologous HSCT based on current capabilities within the EBMT registry core dataset. Data completeness, which has a critical impact on validity of centre comparisons, is also assessed. Ongoing development will include further scientific validation of the model, incorporation of further variables (when appropriate) alongside implementation of systems for clinically meaningful interpretation and governance aiming to maximise acceptance to centres, clinicians, payers and patients across EBMT.

Domaines: Sciences du Vivant [q-bio]

John A. Snowden, Riccardo Saccardi, Kim Orchard, Per Ljungman, Rafael F. Duarte, et al.. Benchmarking of survival outcomes following haematopoietic stem cell transplantation: a review of existing processes and the introduction of an international system from the european society for blood and marrow transplantation (ebmt) and the joint accreditation committee of isct and ebmt (jacie). Bone Marrow Transplantation, 2020, Bone Marrow Transplantation, 55, pp.681-694. ⟨10.1038/s41409-019-0718-7⟩. ⟨hal-04428823⟩