Herpes simplex type 1 primo-infection and pregnancy, two cases of intra-uterine infection and revue of the literature
Résumé
Although 80% of the adult population is seropositive for HSV-1, we describe in this paper two cases of
HSV-1 infection in utero illustrating the risk of HSV-1 associated with primary infection viremia. Clinical histories of
these patients raise concerns with the question of the therapeutic management of gingivostomatitis HSV-1 in pregnant women.
Sixty to eighty percent of the adult population is seropositive for herpes simplex virus type 1 (HSV-1) and 15%
for HSV-2. Despite of this important seroprevalence, primary
infection of the mother during pregnancy leading to fetal
transmission are not rare. Most of HSV infections are neonatal and result from exposure to HSV in the genital tract
during delivery [1]. Although in utero infection resulting from
HSV viremia is rare and barely reported, we report here two
cases of HSV-1 leading to premature labor at 25 WA (week
of amenorrhea) and deaths of newborns, that are raising
concern on the management of HSV primary infection during
pregnancy.
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