A fresh trim provides a new look at the human mannose receptor
Résumé
The human mannose receptor plays an important role in scavenging a variety of glycans and
glycoconjugates which contributes to both innate and adaptive immunity. However, the fine details of
its ligand specificity, and specifically that of CRD4, the most functionally relevant C-type lectin domain
within the receptor, are not completely understood. Feinberg et al. use glycan arrays, crystallography,
and a newly trimmed version of CRD4 to elucidate the molecular mechanisms driving binding specificity.
These data contribute to our molecular understanding of Ca2+ ion-mediated binding promiscuity in the
human mannose receptor and the scavenging role of the receptor itself, and highlight unexpected
interactions that should inspire further study.
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