Non-enzymatic cyclic oxygenated metabolites of omega-3 polyunsaturated fatty acid: Bioactive drugs?

Jérôme Roy (1) , Jean-Yves Le Guennec (1) , Jean-Marie Galano (2) , Jérôme Thireau (1) , Valérie Bultel-Poncé (2) , Marie Demion (1) , Camille Oger (2) , Jetty Chung-Yung Lee (3) , Thierry Durand (2)

1 PhyMedExp - Physiologie & médecine expérimentale du Cœur et des Muscles [U 1046]
2 IBMM - Institut des Biomolécules Max Mousseron [Pôle Chimie Balard]
3 HKU - The University of Hong Kong

Non-enzymatic oxygenated metabolites derived from polyunsaturated fatty acids (PUFA) are formed in vivo through free radical reaction under oxidative stress conditions. It has been over twenty-five years since the discovery of cyclic oxygenated metabolites derived from arachidonic acid (20:4 n-6), the isoprostanes, and since then they have become biomarkers of choice for assessing in vivo OS in humans and animals. Chemical synthesis of n-3 PUFA isoprostanoids such as F3-Isoprostanes from eicosapentaenoic acid (20:5 n-3), and F4-Neuroprostanes from docosahexaenoic acid (22:6 n-6) unravelled novel and unexpected biological properties of such omega-3 non-enzymatic cyclic metabolites as highlighted in this review.

Keywords: Arrhythmia; Isoprostanes; Neuroprostanes; Omega-3 PUFA; Oxidative stress

Domains: Life Sciences [q-bio]

Jérôme Roy, Jean-Yves Le Guennec, Jean-Marie Galano, Jérôme Thireau, Valérie Bultel-Poncé, et al.. Non-enzymatic cyclic oxygenated metabolites of omega-3 polyunsaturated fatty acid: Bioactive drugs?. Biochimie, 2016, 120, pp.56 - 61. ⟨10.1016/j.biochi.2015.06.010⟩. ⟨hal-01786233⟩