Multiple facets of membrane lipids and the diversity of their action mode with special emphasis on the central nervous system
Résumé
This issue of Reproduction Nutrition Development was scheduled along with 8 papers on the metabolism of polyunsaturated fatty acids (PUFAs) and their physiological roles within the central nervous system. Topics focused on PUFAs from the n-3 series, especially on docosahexaenoic acid (DHA) which is particularly abundant in the cell membranes of brain and retina. Reviews and original articles emphasize the impact of n-3 PUFAs on the physical properties of membranes, the neuroprotective mechanisms via Ca2+ signalling in astrocytes, the n-3 status of infants suffering of Attention Deficit Hyperactivity Disorder (ADHD) and the mental development of neonates in relation with maternal feeding. The DHA metabolism in humans and its endogenous production from alpha-linolenic acid is reviewed. Besides, it is described and discussed how the generation of PUFA-derived mediators is modulated by the retinoic acid-receptor signalling via activation of cognate phospholipase activities. The sensitivity and recovering of neurons to oxidative stress is also addressed in this volume, through the description of a model of iron-induced injury in the rat brain. The diversity of these 8 articles illustrates the multiple roles of PUFAs within the central nervous system.
Mots clés
arachidonic acid
astrocytes and calcium signalling
Attention Deficit Hyperactivity Disorder / central nervous sytem
docosahexaenoic acid
endogenous conversion
membrane physical properties
milk and infant mental development
omega-3 and omega-6 fatty acids / oxidative stress
phospholipases
raft
retinoic acid
Origine : Accord explicite pour ce dépôt
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