NMR Determination of Free Gallium(III) Ions in Aqueous Solutions of Ga-complexes, "Cold" Analogs of PET/SPECT Tracers
Résumé
Ga-complexes are widely used as radiopharmaceuticals for PET or SPECT imaging and as therapeutic agents. At physiological pH, free gallium(III) ions can stably exist as soluble gallate [Ga(OH)4]−, a nephrotoxic compound whose presence should be avoided. Any Ga-complex, therefore, should be carefully checked for the absence of gallate before use. Here we show that 71Ga NMR is a useful tool to rapidly detect the presence of gallate in aqueous solutions of Ga-complexes and to follow the purification steps of the Ga-complex solutions.
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