Human metapneumovirus genotypes and Severity of disease in children during a 7-year study in Dijon, France.

Cécile Pitoiset (1) , Magali Darniot (1) , Frédéric Huet (2) , Serge-Ludwig Aho (3) , Pierre P. Pothier (1) , Catherine Manoha (1)

1 Laboratoire de sérologie-virologie (CHU de Dijon)
2 Service de pédiatrie (CHU de Dijon)
3 Service d'épidémiologie et d'hygiène hospitalières (CHU de Dijon)

Human metapneumovirus is a cause of respiratory tract infections at all ages. Our objectives were to analyze the distribution of the A and B genotypes over seven years in Dijon and to investigate a possible association between hMPV genotypes and disease severity. During 2002-2009, we genotyped 100 isolates from children less than three years old with hMPV. Phylogenetic analysis indicated a change in the distribution of hMPV genotype over the years. Severity was then measured by detailed clinical evaluation. The hospitalization rate was greater when genotype B was involved 72.5% vs. 53.3% (p = 0.054). Those infected with genotype B tended to have a higher clinical score, as measured by Vicente et al, 2006, (p = 0.07). We showed that, although clinical severity is not clearly associated with hMPV genotype, pathological signs on chest X-ray were observed more often in B subgroup (p<0.01).

Keywords: Medicine

Cécile Pitoiset, Magali Darniot, Frédéric Huet, Serge-Ludwig Aho, Pierre P. Pothier, et al.. Human metapneumovirus genotypes and Severity of disease in children during a 7-year study in Dijon, France.. Journal of Medical Virology, 2010, 82 (10), pp.1782. ⟨10.1002/jmv.21884⟩. ⟨hal-00570701⟩