Zoledronic acid determines S-phase arrest but fails to induce apoptosis in cholangiocarcinoma cells

Antonello A. Romani , Silvia Desenzani , Marina M. Morganti , Silvia La Monica , Angelo F. Borghetti , Paolo Soliani

Cholangiocarcinoma is the second most common primary hepatic neoplasia and the only curative therapy is surgical resection or liver transplantation. Biphosphonates (BPs) are an emerging class of drugs widely used to treat bone diseases and also appear to possess direct antitumor activity. In two human cholangiocarcinoma cell lines (TFK-1 and EGI-1) we investigated, for the first time, the activity of zoledronic acid by determining proliferation, cell-cycle analysis and apoptosis.

Keywords: Cholangiocarcinoma; Zoledronic acid; Cyclins; Cell cycle regulators; Bcl-xL; GGOH

Antonello A. Romani, Silvia Desenzani, Marina M. Morganti, Silvia La Monica, Angelo F. Borghetti, et al.. Zoledronic acid determines S-phase arrest but fails to induce apoptosis in cholangiocarcinoma cells. Biochemical Pharmacology, 2009, 78 (2), pp.133. ⟨10.1016/j.bcp.2009.04.004⟩. ⟨hal-00493514⟩