System identification of the intracellular photoreaction process induced by photodynamic therapy
Résumé
Photodynamic therapy (PDT) is an alternative treatment for cancer that involves the administration of a photosensitizing agent, which is activated by light at a specific wavelength. This illumination causes a sequence of photoreactions, which - in the presence of molecular oxygen - is supposed to be responsible for the death of the tumor cells. The PDT efficiency stems from the optimal interaction between these three factors (light, drug and oxygen). In this paper, a new approach is proposed to estimate photophysical parameters which characterize the ability of a photosensitizing drug to produce singlet oxygen. This approach is based on system identification techniques. This model-based method would allow biologists to estimate all the photophysical parameters from spectro-fluorescence data generated by only one experiment. Secondly, contrary to usual techniques which are restricted to in vitro studies, this approach can be directly applied to in vivo data.
Domaines
Automatique / Robotique
Origine : Fichiers produits par l'(les) auteur(s)
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