Natural polymorphism of cytomegalovirus DNA polymerase lies in two nonconserved regions located between domains delta-C and II and between domains III and I.
Résumé
We described the natural polymorphism of cytomegalovirus DNA polymerase in 42 unrelated isolates susceptible to ganciclovir, foscarnet, and cidofovir. All variations, including an eight-amino-acid deletion, were located between domains delta-C and II and between domains III and I, suggesting that these specific residues are not involved in enzymatic functions.
Mots clés
Amino Acid Sequence
Amino Acid Substitution
Antiviral Agents/pharmacology
Conserved Sequence
Cytomegalovirus/drug effects/*enzymology/*genetics
DNA-Directed DNA Polymerase/*genetics
Gene Deletion
Humans
Molecular Sequence Data
Phenotype
Polymorphism
Genetic/genetics
Reverse Transcriptase Polymerase Chain Reaction