Dysregulated Tim-3 expression on natural killer cells is associated with increased Galectin-9 levels in HIV-1 infection

Stephanie Jost (1) , Uriel Moreno-Nieves (1) , Wilfredo Garcia-Beltran (1) , Keith Rands (1) , Jeff Reardon (1) , Ildiko Toth (1) , Alicja Piechocka-Trocha (1) , Marcus Altfeld (1, 2) , Marylyn Addo (1)

1 Ragon Institute of MGH, MIT and Harvard
2 Heinrich-Pette-Institut

Natural killer (NK) cells constitutively express high levels of Tim-3, an immunoregulatory molecule recently proposed to be a marker for mature and functional NK cells. Whether HIV-1 infection modulates the expression of Tim-3 on NK cells, or the levels of its ligand Galectin-9 (Gal-9), and how signaling through these molecules affects the NK cell response to HIV-1 remains inadequately understood.

Domaines: Maladies infectieuses

Stephanie Jost, Uriel Moreno-Nieves, Wilfredo Garcia-Beltran, Keith Rands, Jeff Reardon, et al.. Dysregulated Tim-3 expression on natural killer cells is associated with increased Galectin-9 levels in HIV-1 infection. Retrovirology, 2013, 10 (1), pp.74. ⟨10.1186/1742-4690-10-74⟩. ⟨pasteur-00851174⟩