Skip to Main content Skip to Navigation
Journal articles

Identifying neural drivers with functional MRI: an electrophysiological validation.: Identifying neural drivers with fMRI

Abstract : Whether functional magnetic resonance imaging (fMRI) allows the identification of neural drivers remains an open question of particular importance to refine physiological and neuropsychological models of the brain, and/or to understand neurophysiopathology. Here, in a rat model of absence epilepsy showing spontaneous spike-and-wave discharges originating from the first somatosensory cortex (S1BF), we performed simultaneous electroencephalographic (EEG) and fMRI measurements, and subsequent intracerebral EEG (iEEG) recordings in regions strongly activated in fMRI (S1BF, thalamus, and striatum). fMRI connectivity was determined from fMRI time series directly and from hidden state variables using a measure of Granger causality and Dynamic Causal Modelling that relates synaptic activity to fMRI. fMRI connectivity was compared to directed functional coupling estimated from iEEG using asymmetry in generalised synchronisation metrics. The neural driver of spike-and-wave discharges was estimated in S1BF from iEEG, and from fMRI only when hemodynamic effects were explicitly removed. Functional connectivity analysis applied directly on fMRI signals failed because hemodynamics varied between regions, rendering temporal precedence irrelevant. This paper provides the first experimental substantiation of the theoretical possibility to improve interregional coupling estimation from hidden neural states of fMRI. As such, it has important implications for future studies on brain connectivity using functional neuroimaging.
Document type :
Journal articles
Complete list of metadatas

Cited literature [81 references]  Display  Hide  Download

https://www.hal.inserm.fr/inserm-00356680
Contributor : Olivier David <>
Submitted on : Wednesday, January 28, 2009 - 11:26:55 AM
Last modification on : Thursday, February 1, 2018 - 1:11:42 AM
Long-term archiving on: : Tuesday, June 8, 2010 - 9:32:02 PM

File

David_2008_NeuralDriversfMRI.p...
Publisher files allowed on an open archive

Identifiers

Collections

U836 | UGA

Citation

Olivier David, Isabelle Guillemain, Sandrine Saillet, Sebastien Reyt, Colin Deransart, et al.. Identifying neural drivers with functional MRI: an electrophysiological validation.: Identifying neural drivers with fMRI. PLoS Biology, Public Library of Science, 2008, 6 (12), pp.2683-97. ⟨10.1371/journal.pbio.0060315⟩. ⟨inserm-00356680⟩

Share

Metrics

Record views

763

Files downloads

395