Obesity Doubles Mortality in Patients Hospitalized for Severe Acute Respiratory Syndrome Coronavirus 2 in Paris Hospitals, France: A Cohort Study on 5,795 Patients

Sébastien Czernichow (1) , Nathanael Beeker (2) , Claire Rives‐lange (1) , Emmanuel Guerot (1) , Jean‐luc Diehl (3) , Sandrine Katsahian (1) , Jean‐sébastien Hulot (4) , Tigran Poghosyan (1) , Claire Carette (1) , Anne‐sophie Jannot (5) , Pierre‐yves Ancel , Alain Bauchet , Vincent Benoit , Mélodie Bernaux , Ali Bellamine , Romain Bey , Aurélie Bourmaud , Stéphane Bréant , Anita Burgun , Fabrice Carrat , Charlotte Caucheteux , Julien Champ , Sylvie Cormont , Christel Daniel (6) , Julien Dubiel , Catherine Ducloas , Loic Esteve , Marie Frank , Nicolas Garcelon , Alexandre Gramfort , Nicolas Griffon , Olivier Grisel , Martin Guilbaud , Claire Hassen‐khodja , François Hemery , Martin Hilka , Anne Sophie Jannot , Jerome Lambert , Richard Layese , Judith Leblanc , Léo Lebouter , Guillaume Lemaitre , Damien Leprovost , Ivan Lerner , Kankoe Levi Sallah , Aurélien Maire , Marie‐france Mamzer , Patricia Martel , Arthur Mensch , Thomas Moreau , Antoine Neuraz , Nina Orlova , Nicolas Paris , Bastien Rance , Hélène Ravera , Antoine Rozes , Elisa Salamanca , Arnaud Sandrin , Patricia Serre , Xavier Tannier (6) , Jean‐marc Treluyer , Damien van Gysel , Gael Varoquaux , Jill Jen Vie , Maxime Wack , Perceval Wajsburt , Demian Wassermann , Eric Zapletal

1 HEGP - Hôpital Européen Georges Pompidou [APHP]
2 Hôpital Cochin [AP-HP]
3 UPCité - Université Paris Cité
4 CIC 1418 - CIC - HEGP
5 CRC (UMR_S_1138 / U1138) - Centre de Recherche des Cordeliers
6 LIMICS - Laboratoire d'Informatique Médicale et Ingénierie des Connaissances en e-Santé

Objective Preliminary data from different cohorts of small sample size or with short follow‐up indicate poorer prognosis in people with obesity compared with other patients. This study aims to precisely describe the strength of association between obesity in patients hospitalized with coronavirus disease 2019 (COVID‐19) and mortality and to clarify the risk according to usual cardiometabolic risk factors in a large cohort. Methods This is a prospective cohort study including 5,795 patients aged 18 to 79 years hospitalized from February 1 to April 30, 2020, in the Paris area, with confirmed infection by severe acute respiratory syndrome coronavirus 2. Adjusted regression models were used to estimate the odds ratios (ORs) and 95% CIs for the mortality rate at 30 days across BMI classes, without and with imputation for missing BMI values. Results Eight hundred ninety‐one deaths had occurred at 30 days. Mortality was significantly raised in people with obesity, with the following ORs for BMI of 30 to 35 kg/m2, 35 to 40 kg/m2, and >40 kg/m2: 1.89 (95% CI: 1.45‐2.47), 2.79 (95% CI: 1.95‐3.97), and 2.55 (95% CI: 1.62‐3.95), respectively (18.5‐25 kg/m2 was used as the reference class). This increase holds for all age classes. Conclusions Obesity doubles mortality in patients hospitalized with COVID‐19.

Domaines: Sciences du Vivant [q-bio]

Sébastien Czernichow, Nathanael Beeker, Claire Rives‐lange, Emmanuel Guerot, Jean‐luc Diehl, et al.. Obesity Doubles Mortality in Patients Hospitalized for Severe Acute Respiratory Syndrome Coronavirus 2 in Paris Hospitals, France: A Cohort Study on 5,795 Patients. Obesity, 2020, 28 (12), pp.2282-2289. ⟨10.1002/oby.23014⟩. ⟨hal-03677189⟩