Palladium-Catalyzed Oxidative sp 2 C−H Bond Acylation with Alcohols

Fuhong Xiao (1) , Qi Shuai (2) , Feng Zhao (1) , Olivier Baslé (2) , Guojun Deng (1) , Chao-Jun Li (2)

1 Xiangtan University
2 Department of Chemistry [Montréal]

An efficient method was developed for the direct acylation of arene sp2 C−H bonds with alcohols using palladium chloride as a catalyst and peroxide as the oxidant. The alcohols were oxidized to their corresponding aldehydes in situ and efficiently coupled with 2-arylpyridines to give aryl ketones in chlorobenzene.

Mots clés: Alcohols; Organic reactions; Post-translational modification; Aldehydes; Pharmaceuticals

Domaines: Chimie de coordination

Fuhong Xiao, Qi Shuai, Feng Zhao, Olivier Baslé, Guojun Deng, et al.. Palladium-Catalyzed Oxidative sp 2 C−H Bond Acylation with Alcohols. Organic Letters, 2011, 13 (7), pp.1614-1617. ⟨10.1021/ol200017a⟩. ⟨hal-03652873⟩