Copper-catalyzed aerobic phosphonation of sp3 C–H bonds

Olivier Baslé (1) , Chao-Jun Li (1)

1 Department of Chemistry [Montréal]

An efficient cross-dehydrogenative-coupling (CDC) between sp3 C–H and H–P bonds was developed using copper salt as catalyst and molecular oxygen as terminal oxidant; this new methodology provides an easy access to biologically important α-aminophosphonates.

Domaines: Chimie de coordination

Olivier Baslé, Chao-Jun Li. Copper-catalyzed aerobic phosphonation of sp3 C–H bonds. Chemical Communications, 2009, 27, pp.4124-4126. ⟨10.1039/B905275E⟩. ⟨hal-03652774⟩