Adaptation of CytoProcessor for cervical cancer screening of challenging slides

Elizabeth F Crowell (1) , Cyril Bazin , Vianney Thurotte , Hubert Elie (2) , Laurette Jitaru (2) , Grégoire Olivier (2) , Yann Caillot , Romain Brixtel , Boris Lesner , Matthieu Toutain , Arnaud Renouf

1 Datexim
2 Service d'anatomie et de cytologie pathologiques [CHPC - Site Louis Pasteur]

Background Current automated cervical cytology screening systems require purchase of a dedicated preparation machine and use of a specific staining protocol. CytoProcessor (DATEXIM, Caen, France) is a new automated system, designed to integrate seamlessly into the laboratory's existing workflow. We previously demonstrated the superior performance of CytoProcessor for diagnosis of ThinPrep slides compared to the ThinPrep Imaging System (HOLOGIC, Marlborough, MA). Next, we analyzed whether CytoProcessor technology can be adapted for use on Novaprep slides. Methods Using artificial intelligence, we developed a new algorithm in CytoProcessor for the analysis of slides prepared using the NOVAPREP Processor System NPS50 (Novacyt, Vélizy-Villacoublay, France). A representative population of 309 cases was selected from the routine workflow in a public hospital. We compared the diagnoses made using CytoProcessor or conventional screening with a microscope. All discordances were resolved by a consensus committee. Results The performance of CytoProcessor in terms of diagnostic accuracy on Novaprep slides was very similar to that observed previously on ThinPrep slides. Compared to conventional screening, CytoProcessor slightly improves diagnostic sensitivity while maintaining a statistically equivalent specificity. Diagnosis was reached 1.6 times faster with CytoProcessor compared to using a microscope. Conclusion CytoProcessor is a robust automated cervical cytology screening system that can be used successfully with samples having very different characteristics. As previously shown, CytoProcessor confers significant gains in processing time and diagnostic precision. CytoProcessor is accessible through a secured internet connection, making remote diagnosis of Papanicolaou tests possible.

Mots clés: artificial intelligence; cervical screening; digital pathology; gynecologic cytology; Papanicolaou test

Domaines: Cancer; Anatomie, Histologie, Anatomopathologie [q-bio.TO]; Médecine humaine et pathologie; Gynécologie et obstétrique; Sciences du Vivant [q-bio]

Elizabeth F Crowell, Cyril Bazin, Vianney Thurotte, Hubert Elie, Laurette Jitaru, et al.. Adaptation of CytoProcessor for cervical cancer screening of challenging slides. Diagnostic Cytopathology, 2019, Diagnostic Cytopathology, 47 (9), pp.890-897. ⟨10.1002/dc.24213⟩. ⟨hal-03497879⟩