Activity measurements and determination of nuclear decay data of $^{166}$Ho in the MRTDosimetry project

Christophe Bobin (1) , Jacques Bouchard (1) , Vanessa Chisté (1) , S.M. Collins (2) , P. Dryák (3) , A. Fenwick (2) , J. Keightley (2) , Marie-Christine Lépy (1) , Valérie Lourenço (1) , A.P. Robinson (2) , J. Sochorová (3) , J. Šolc (3) , Cheick Thiam (1)

1 LNHB (CEA, LIST) - Laboratoire National Henri Becquerel (CEA, LIST)
2 NPL - National Physical Laboratory [Teddington]
3 Czech Metrology Institute

Holmium-166 is a high-energy β$^−$-emitter radionuclide (~ 1.8 MeV) with a short half-life that offers great potential as an alternative to 90Y for the treatment of liver cancer based on radioembolization. The possibility of quantitative Single Photon Emission Computed Tomography (SPECT) imaging of the main γ-ray emission at 80.6 keV, in addition to strong paramagnetic properties suitable for Magnetic Resonance Imaging (MRI), complement this therapeutic potential. The present paper describes the measurements carried out in three European radionuclide metrology laboratories for primary standardization of 166Ho and new determinations of X- and γ-ray photon-emission intensities in the framework of the European EMPIR project MRTDosimetry. New half-life measurements were also performed.

Mots clés: Ho-166; Activity standardization; Gamma-spectrometry; Half-life measurements; Molecular radiotherapy; MRTDosimetry project; metrology; ionizing radiation; beta-rays; gamma-rays; X-rays; Radioactivity; spectrometry; Decay data measurement

Domaines: Physique Nucléaire Expérimentale [nucl-ex]; Instrumentations et Détecteurs [physics.ins-det]

Christophe Bobin, Jacques Bouchard, Vanessa Chisté, S.M. Collins, P. Dryák, et al.. Activity measurements and determination of nuclear decay data of $^{166}$Ho in the MRTDosimetry project. Applied Radiation and Isotopes, 2019, 153, pp.108826. ⟨10.1016/j.apradiso.2019.108826⟩. ⟨hal-03433603⟩