Reprogramming: Emerging Strategies to Rejuvenate Aging Cells and Tissues

Quentin Alle (1) , Enora Le Borgne (1) , Ollivier Milhavet (1) , Jean-Marc Lemaitre (1)

1 Cellules Souches, Plasticité Cellulaire, Médecine Régénératrice et Immunothérapies (IRMB)

Aging is associated with a progressive and functional decline of all tissues and a striking increase in many “age-related diseases”. Although aging has long been considered an inevitable process, strategies to delay and potentially even reverse the aging process have recently been developed. Here, we review emerging rejuvenation strategies that are based on reprogramming toward pluripotency. Some of these approaches may eventually lead to medical applications to improve healthspan and longevity.

Mots clés: aging; senescence; epigenetics; stem cells; reprogramming; iPSC

Domaines: Sciences du Vivant [q-bio]

Quentin Alle, Enora Le Borgne, Ollivier Milhavet, Jean-Marc Lemaitre. Reprogramming: Emerging Strategies to Rejuvenate Aging Cells and Tissues. International Journal of Molecular Sciences, 2021, 22 (8), pp.3990. ⟨10.3390/ijms22083990⟩. ⟨hal-03359763⟩