Nutrition, inflammation and depression
Résumé
The fatty acid composition of cell membranes is critical for the synthesis of lipidic mediators during the inflammatory response and then for the intensity and duration of the inflammation. n-3 polyunsaturated fatty acids (n-3 PUFAs) inhibited the production of pro-inflammatory cytokines and enhanced the production of anti-inflammatory cytokines. The bioactive lipidic mediators synthesized from n-3 PUFAs such as resolvins, maresins, neuroprotectins are responsible for at least some of the anti-inflammatory effects that have been attributed to n-3 PUFAs. Eicosapentaenoic acid has a role in the regulation of mood. Subjects identified as being high on pro-inflammatory markers were more likely to respond to EPA than placebo.